ENTACAPONE OR TOLCAPONE AND TRICYCLICS
Studies suggest that no important interaction occurs between entacapone and imipramine or between tolcapone and desipramine.
Despite these studies, the manufacturer of entacapone says there is limited clinical experience of the use of entacapone with tricyclic antidepressants, and they therefore recommend caution. Similarly, the manufacturers of tolcapone suggest that caution should be exercised if desipramine is taken concurrently.
Despite these studies, the manufacturer of entacapone says there is limited clinical experience of the use of entacapone with tricyclic antidepressants, and they therefore recommend caution. Similarly, the manufacturers of tolcapone suggest that caution should be exercised if desipramine is taken concurrently.