ERGOT DERIVATIVES AND RIFAMPICIN (RIFAMPIN)

Rifampicin is predicted to increase the metabolism of ergot derivatives, and might therefore be expected to reduce their efficacy. Note that rifampicin has been used as a potent enzyme inducer to reduce ergotamine levels in a patient with ergotism, and was said to play a key role in reducing ergotamine levels.
Monitor the outcome of concurrent use to ensure the effects of ergot derivatives are adequate.