ETHOSUXIMIDE AND VALPROATE
Sodium valproate has increased the serum levels of ethosuximide by about 50%. Sedation occurred and ethosuximide dose reductions were necessary. However, other studies have described no changes or even reduced ethosuximide levels when valproate was also given. Ethosuximide may also lower valproate serum levels.
Monitor the effects of concurrent use, adjusting the ethosuximide dose and increasing the valproate dose accordingly. Valproate levels may be helpful.
Monitor the effects of concurrent use, adjusting the ethosuximide dose and increasing the valproate dose accordingly. Valproate levels may be helpful.