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ETOPOSIDE AND HERBAL MEDICINES OR DIETARY SUPPLEMENTS

Medical Diagnosis and Drugs, Medications
In vitro studies suggest that hypericin, a component of St John's wort (Hypericum perforatum) may antagonise the antineoplastic effects of etoposide. It may also stimulate the hepatic metabolism of etoposide by CYP3A4.
Information is very limited but what is known suggests that it would be prudent to avoid St John's wort in patients taking etoposide.
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