FLECAINIDE AND NSAIDS
Because valdecoxib (the metabolite of parecoxib) increases dextromethorphan levels by about 3-fold the manufacturers predict that the levels of flecainide (which is similarly metabolised) will also be raised by valdecoxib.
The general importance of this interaction is unclear, but be aware that the effects of flecainide may be increased.
The general importance of this interaction is unclear, but be aware that the effects of flecainide may be increased.