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FOLATES AND METHOTREXATE

Medical Diagnosis and Drugs, Medications
Folic acid or folinic acid are sometimes added if low-dose methotrexate is given for rheumatoid arthritis or psoriasis to reduce adverse effects. Folinic acid is frequently used to minimise toxicity with high-dose methotrexate in cancer therapy.
Patients taking methotrexate should avoid the inadvertent use of folates in multivitamin preparations.
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