FOOD AND NSAIDS
Food reduces the rate of absorption but has no or little effect on the extent of absorption of most NSAIDs. The extent of ketoprofen absorption is reduced by food.
The small changes seen will have no clinical relevance if these drugs are being used regularly to treat chronic pain and inflammation. However, if they are being used for the treatment of acute pain, administration on an empty stomach would be preferable in terms of onset of effect. However, it is usually recommended that NSAIDs (including ketoprofen) are given with or after food, in an attempt to minimise their gastrointestinal adverse effects.
The small changes seen will have no clinical relevance if these drugs are being used regularly to treat chronic pain and inflammation. However, if they are being used for the treatment of acute pain, administration on an empty stomach would be preferable in terms of onset of effect. However, it is usually recommended that NSAIDs (including ketoprofen) are given with or after food, in an attempt to minimise their gastrointestinal adverse effects.