FOOD AND PROTEASE INHIBITORS
Food increases the bioavailability of atazanavir, darunavir, lopinavir, nelfinavir, saquinavir, and tipranavir, but decreases that of indinavir. Food only minimally affects the bioavailability of amprenavir, fosamprenavir and ritonavir.
Indinavir should be given one hour before or 2 hours after meals, or with light
meals only. Atazanavir, darunavir, lopinavir, nelfinavir, and tipranavir should be taken with food to enhance bioavailability. Saquinavir (soft and hard capsules) should be taken up to 2 hours after a meal. The US manufacturers of amprenavir say that it should not be given with high-fat meals, but otherwise it may be given with or without food.
Indinavir should be given one hour before or 2 hours after meals, or with light
meals only. Atazanavir, darunavir, lopinavir, nelfinavir, and tipranavir should be taken with food to enhance bioavailability. Saquinavir (soft and hard capsules) should be taken up to 2 hours after a meal. The US manufacturers of amprenavir say that it should not be given with high-fat meals, but otherwise it may be given with or without food.