GANCICLOVIR AND NRTIS - ZIDOVUDINE
Anaemia, neutropenia, leucopenia and gastrointestinal disturbances were seen when zidovudine and ganciclovir were used concurrently. The dose of zidovudine had to be reduced to 300 mg daily in many patients. Ganciclovir appears to moderately increase the levels of zidovudine. Valganciclovir is a prodrug of ganciclovir and would therefore be expected to interact similarly.
The UK manufacturer of ganciclovir suggests that zidovudine should not be iven during ganciclovir induction treatment, and patients should be closely monitored for neutropenia when maintenance ganciclovir is used with zidovudine.
The UK manufacturer of ganciclovir suggests that zidovudine should not be iven during ganciclovir induction treatment, and patients should be closely monitored for neutropenia when maintenance ganciclovir is used with zidovudine.