GRISEOFULVIN AND PHENOBARBITAL
The antifungal effects of griseofulvin can be reduced (serum levels reduced by about one-third) or even abolished by the concurrent use of phenobarbital. Note that primidone is metabolised to phenobarbital and may therefore interact similarly.
Concurrent use should be well monitored to confirm that griseofulvin is effective. If appropriate, a non-interacting antiepileptic such as sodium valproate may be considered.
Concurrent use should be well monitored to confirm that griseofulvin is effective. If appropriate, a non-interacting antiepileptic such as sodium valproate may be considered.