H2-RECEPTOR ANTAGONISTS AND MACROLIDES
Cimetidine can almost double the serum levels of erythromycin, although this has only been seen in a single dose study. A single case report describes reversible deafness attributed to this interaction.
Evidence for this interaction is very limited. However, it may be prudent to be alert for erythromycin adverse effects (nausea, vomiting, diarrhoea, abdominal dis- comfort). Ranitidine is a possible non-interacting alternative, as are azithromycin and clarithromycin.
Evidence for this interaction is very limited. However, it may be prudent to be alert for erythromycin adverse effects (nausea, vomiting, diarrhoea, abdominal dis- comfort). Ranitidine is a possible non-interacting alternative, as are azithromycin and clarithromycin.