H2-RECEPTOR ANTAGONISTS AND OPIOIDS
Cimetidine increases the plasma levels of alfentanil, and some preliminary observa- tions suggest that cimetidine may increase the effects of fentanyl. Isolated reports describe adverse reactions in patients taking methadone, morphine, or mixed opium alkaloids when cimetidine was also given, or morphine when ranitidine was also given.
The clinical relevance of these effects on alfentanil and fentanyl are unknown. The case reports are not expected to be of general significance.
The clinical relevance of these effects on alfentanil and fentanyl are unknown. The case reports are not expected to be of general significance.