H2-RECEPTOR ANTAGONISTS AND PHOSPHODIESTERASE TYPE-5 INHIBITORS
Cimetidine increases the AUC of sildenafil by 56%.
The UK manufacturer of sildenafil suggests that a low starting dose of 25 mg should be used if cimetidine is given, although the modest increase in levels seems unlikely to cause particular problems. The US manufacturers do not recommend any additional precautions.
The UK manufacturer of sildenafil suggests that a low starting dose of 25 mg should be used if cimetidine is given, although the modest increase in levels seems unlikely to cause particular problems. The US manufacturers do not recommend any additional precautions.