H2-RECEPTOR ANTAGONISTS AND SSRIS
Citalopram, escitalopram, paroxetine and sertraline levels are moderately increased by cimetidine.
Initial dosage reductions are not needed, but be aware that some patients may have an increase in SSRI adverse effects (dry mouth, nausea, diarrhoea, dyspepsia, tremor, ejaculatory delay, sweating), in which case dose reductions may be appropriate. Although not proven, it is thought that ranitidine and famotidine are unlikely to interact.
Initial dosage reductions are not needed, but be aware that some patients may have an increase in SSRI adverse effects (dry mouth, nausea, diarrhoea, dyspepsia, tremor, ejaculatory delay, sweating), in which case dose reductions may be appropriate. Although not proven, it is thought that ranitidine and famotidine are unlikely to interact.