H2-RECEPTOR ANTAGONISTS AND TRICYCLICS
The concurrent use of cimetidine can raise the plasma levels of amitriptyline, desipramine, doxepin, imipramine and nortriptyline. Severe adverse effects have occurred in a few patients. Other tricyclic antidepressants are expected to interact similarly.
Patients taking tricyclics and cimetidine should be monitored for evidence of increased toxicity (dry mouth, urinary retention, blurred vision, constipation, tachycardia, postural hypotension). Reduce the tricyclic dose if necessary. Ranitidine does not appear to interact.
Patients taking tricyclics and cimetidine should be monitored for evidence of increased toxicity (dry mouth, urinary retention, blurred vision, constipation, tachycardia, postural hypotension). Reduce the tricyclic dose if necessary. Ranitidine does not appear to interact.