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HERBAL MEDICINES OR DIETARY SUPPLEMENTS AND HRT

Medical Diagnosis and Drugs, Medications
The hormones in HRT are similar to those used in hormonal contraceptives, and so may be affected by enzyme-inducing drugs, such as St John's wort (Hypericum perforatum), in the same way as contraceptives. Reduced effects are therefore possible.
Any interaction would be most likely to be noticed where HRT is prescribed for menopausal vasomotor symptoms, but might be difficult to detect where the indication is osteoporosis. Further study is needed to confirm the importance of this possible interaction.
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