HERBAL MEDICINES OR DIETARY SUPPLEMENTS AND SIROLIMUS
The manufacturers of sirolimus predict that St John's wort (Hypericum perforatum) may lower its serum levels, probably because rifampicin (rifampin), another CYP3A4 inducer, has been shown to do so.
The extent of any change in sirolimus levels is uncertain, but if concurrent use cannot be avoided it would seem prudent to increase the frequency of monitoring of sirolimus levels.
The extent of any change in sirolimus levels is uncertain, but if concurrent use cannot be avoided it would seem prudent to increase the frequency of monitoring of sirolimus levels.