HRT AND TACRINE
HRT increases the AUC of tacrine by 60% (and even up to 3-fold in one individual) and reduces the clearance by about 30%.
The importance of this interaction is unclear. Increased tacrine levels may increase both the efficacy and adverse effects of tacrine. Monitor patients for signs of tacrine toxicity and consider a tacrine dose reduction if indicated.
The importance of this interaction is unclear. Increased tacrine levels may increase both the efficacy and adverse effects of tacrine. Monitor patients for signs of tacrine toxicity and consider a tacrine dose reduction if indicated.