IRON AND LEVODOPA
The absorption of levodopa can be reduced by 30 to 50% by ferrous sulfate due to levodopa chelation. Therefore all iron compounds are expected to act similarly. Carbidopa levels are also reduced. There is some evidence that this interaction causes a decrease in symptom control.
Separating the administration of the iron as much as possible is likely to be an effective way of managing this interaction.
Separating the administration of the iron as much as possible is likely to be an effective way of managing this interaction.