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LEVODOPA AND MAOIS

Medical Diagnosis and Drugs, Medications
A rapid, serious and potentially life-threatening hypertensive reaction can occur in patients taking MAOIs if they are also given levodopa.
An interaction with levodopa given with carbidopa or benserazide is unlikely. Even so, the manufacturers continue to list the MAOIs among their contraindi- cations and say that patients should not be given levodopa during treatment with MAOIs, nor for a period of 2 to 3 weeks after their withdrawal.
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