LEVODOPA AND METOCLOPRAMIDE

Metoclopramide is a centrally-acting dopamine antagonist, which can oppose the effects of levodopa and worsen Parkinson's disease. It also stimulates gastric emptying and this may lead to a small increase in the bioavailability of levodopa.
Concurrent use should generally be avoided. Domperidone is the antiemetic of choice in Parkinson's disease.