LEVODOPA AND PYRIDOXINE
The effects of levodopa are reduced or abolished by pyridoxine, but this interaction does not occur when levodopa is given with the dopa-decarboxylase inhibitors carbidopa or benserazide, as is usual clinical practice.
In the rare cases that levodopa is used alone, pyridoxine in doses as low as 5 mg daily can reduce the effects of levodopa and should therefore be avoided. Warn patients about proprietary pyridoxine-containing preparations such as multi- vitamins and supplements. There is no evidence to suggest that a low-pyridoxine diet is desirable.
In the rare cases that levodopa is used alone, pyridoxine in doses as low as 5 mg daily can reduce the effects of levodopa and should therefore be avoided. Warn patients about proprietary pyridoxine-containing preparations such as multi- vitamins and supplements. There is no evidence to suggest that a low-pyridoxine diet is desirable.