LEVOTHYROXINE AND PHENYTOIN
An isolated report describes a patient, previously well maintained on levothyroxine, who developed clinical hypothyroidism when also given phenytoin. Phenytoin can
reduce endogenous serum thyroid hormone levels, but clinical hypothyroidism caused by an interaction seems to be rare.
The general importance of this interaction seems small, but be alert for any evidence of changes in thyroid status if phenytoin is added or withdrawn from patients taking levothyroxine.
reduce endogenous serum thyroid hormone levels, but clinical hypothyroidism caused by an interaction seems to be rare.
The general importance of this interaction seems small, but be alert for any evidence of changes in thyroid status if phenytoin is added or withdrawn from patients taking levothyroxine.