LEVOTHYROXINE AND TRICYCLICS

The antidepressant response to imipramine, amitriptyline and possibly other tricyclics can be accelerated by the use of thyroid hormones. Isolated cases of paroxysmal atrial tachycardia, thyrotoxicosis and hypothyroidism due to concurrent therapy have been described.
These apparent interactions remain unexplained. Unless problems arise there would seem to be no good reason for avoiding concurrent use.