LIDOCAINE AND PHENOBARBITAL
Plasma lidocaine levels, following slow intravenous injection, may be up to about 30% lower in patients who are taking phenobarbital. It seems likely that other barbiturates will interact similarly.
It may be necessary to increase the dosage of lidocaine to achieve the desired therapeutic response in patients taking barbiturates.
It may be necessary to increase the dosage of lidocaine to achieve the desired therapeutic response in patients taking barbiturates.