LIDOCAINE AND PHENYTOIN
The incidence of central adverse effects may be increased following the concurrent use of lidocaine and phenytoin. Sinoatrial arrest has been reported in one patient receiving the combination. Lidocaine levels may be reduced by phenytoin. Fosphenytoin, a prodrug of phenytoin, may interact similarly.
The clinical significance of this interaction is most likely to be small. However, the arrest emphasises the need to exercise caution when giving two drugs that have cardiodepressant actions.
The clinical significance of this interaction is most likely to be small. However, the arrest emphasises the need to exercise caution when giving two drugs that have cardiodepressant actions.