LINEZOLID AND OPIOIDS

The use of pethidine (meperidine) with MAOIs has resulted in a potentially life- threatening reaction in a few patients. Excitement, muscle rigidity, hyperpyrexia, flushing, sweating and unconsciousness occur very rapidly. Respiratory depression and hypotension have also been seen. Because linezolid has weak MAOI properties the manufacturers predict it may interact similarly.
Avoid concurrent use.