MACROLIDES AND PHENYTOIN - CLARITHROMYCIN
Preliminary evidence suggests that clarithromycin may raise serum phenytoin levels. Fosphenytoin, a prodrug of phenytoin, may interact similarly.
The clinical importance of this interaction is unknown, but bear it in mind in case of an unexpected response to treatment. Indicators of phenytoin toxicity include blurred vision, nystagmus, ataxia or drowsiness. Note that erythromycin does not appear to interact.
The clinical importance of this interaction is unknown, but bear it in mind in case of an unexpected response to treatment. Indicators of phenytoin toxicity include blurred vision, nystagmus, ataxia or drowsiness. Note that erythromycin does not appear to interact.