MACROLIDES AND PHENYTOIN - TELITHROMYCIN
Phenytoin possibly reduces telithromycin levels, which may reduce its efficacy. Fosphenytoin, a prodrug of phenytoin, may interact similarly.
The manufacturers say to avoid telithromycin use during and up to 2 weeks after phenytoin treatment. Note that erythromycin does not appear to interact.
The manufacturers say to avoid telithromycin use during and up to 2 weeks after phenytoin treatment. Note that erythromycin does not appear to interact.