MACROLIDES AND PROTEASE INHIBITORS - CLARITHROMYCIN WITH ATAZANAVIR
Atazanavir almost doubled the AUC of clarithromycin, and reduced the AUC of its active metabolite by 70%, while clarithromycin increased the AUC of atazanavir by 28%.
Reducing the dose of clarithromycin to avoid high levels may result in subtherapeutic levels of the active metabolite. The US manufacturer says that, other than for Mycobacterium avium complex infections, an alternative to clarithromycin should be considered. If the combination is used they suggest a 50% dose reduction for the clarithromycin. The UK manufacturer recommends caution.
Reducing the dose of clarithromycin to avoid high levels may result in subtherapeutic levels of the active metabolite. The US manufacturer says that, other than for Mycobacterium avium complex infections, an alternative to clarithromycin should be considered. If the combination is used they suggest a 50% dose reduction for the clarithromycin. The UK manufacturer recommends caution.