MACROLIDES AND PROTEASE INHIBITORS - TELITHROMYCIN WITH RITONAVIR

Ketoconazole increases the AUC of telithromycin 2-fold. Because ritonavir is a more potent enzyme inhibitor than ketoconazole the manufacturers predict that the exposure to telithromycin may be greater than 2-fold in the presence of ritonavir.
The manufacturers advise caution on concurrent use. Monitor for telithromycin adverse effects (such as diarrhoea, dizziness and headache).