MACROLIDES AND SIROLIMUS
Two patients had large elevations in their sirolimus levels following the addition of erythromycin.
This interaction is in line with the manufacturer's prediction. They also predict that other inhibitors of CYP3A4 (they name clarithromycin and telithromycin) will interact similarly, and should be avoided. Note that the macrolides differ in their ability to inhibit CYP3A4, see macrolides. Other macrolides seem less likely to interact.
This interaction is in line with the manufacturer's prediction. They also predict that other inhibitors of CYP3A4 (they name clarithromycin and telithromycin) will interact similarly, and should be avoided. Note that the macrolides differ in their ability to inhibit CYP3A4, see macrolides. Other macrolides seem less likely to interact.