MAO-B INHIBITORS AND MOCLOBEMIDE
The combination of an MAO-A inhibitor (moclobemide) with an MAO-B inhibitor (selegiline or rasagiline) causes MAO inhibition similar to that seen with the non-selective MAOIs.
Patients should be given the same dietary restrictions about tyramine-rich foods and drinks (cheese, some wines and beers, etc.), which relate to the non-selective MAOIs, although the risks are less. See food. It is suggested that if selegiline is replaced by moclobemide, the dietary restrictions can be relaxed after a wash-out period of about 2 weeks. If switching from moclobemide to selegiline, a wash-out period of 1 to 2 days is sufficient. Similar advice would seem prudent with rasagiline. Note that all of the interactions of the non-selective MAOIs, are likely to apply to patients taking this combination.
Patients should be given the same dietary restrictions about tyramine-rich foods and drinks (cheese, some wines and beers, etc.), which relate to the non-selective MAOIs, although the risks are less. See food. It is suggested that if selegiline is replaced by moclobemide, the dietary restrictions can be relaxed after a wash-out period of about 2 weeks. If switching from moclobemide to selegiline, a wash-out period of 1 to 2 days is sufficient. Similar advice would seem prudent with rasagiline. Note that all of the interactions of the non-selective MAOIs, are likely to apply to patients taking this combination.