MAO-B INHIBITORS AND SSRIS
Although safe concurrent use of selegiline and SSRIs has been reported in a number of patients, there are also documented cases of serotonin syndrome. Rasagiline is expected to interact similarly.
The manufacturers of rasagiline recommend avoiding combined use with fluoxetine and fluvoxamine. Rasagiline should not be started for 5 weeks after stopping fluoxetine or 2 weeks after starting fluvoxamine, and fluoxetine should not be started for 2 weeks after stopping rasagiline. They recommend caution with other SSRI antidepressants because of this risk. The manufacturers of selegiline contraindicate the concurrent use of SSRIs. In addition, selegiline should not be started for 5 weeks after stopping fluoxetine, 2 weeks after stopping sertraline, and one week after stopping other SSRIs. SSRIs should not be started for 2 weeks after stopping selegiline.
The manufacturers of rasagiline recommend avoiding combined use with fluoxetine and fluvoxamine. Rasagiline should not be started for 5 weeks after stopping fluoxetine or 2 weeks after starting fluvoxamine, and fluoxetine should not be started for 2 weeks after stopping rasagiline. They recommend caution with other SSRI antidepressants because of this risk. The manufacturers of selegiline contraindicate the concurrent use of SSRIs. In addition, selegiline should not be started for 5 weeks after stopping fluoxetine, 2 weeks after stopping sertraline, and one week after stopping other SSRIs. SSRIs should not be started for 2 weeks after stopping selegiline.