MAO-B INHIBITORS AND TRICYCLICS
Rare cases of serotonin syndrome, and other CNS disturbances have been seen when selegiline is given with tricyclics. Rasagiline is expected to interact similarly.
If the combination is used the outcome should be well monitored, but the likelihood of problems seems to be small. Nevertheless, some manufacturers of selegiline advise avoiding the combination of tricyclic antidepressants and selegiline. The manufacturers of rasagiline advise caution if it is given with antidepressants.
If the combination is used the outcome should be well monitored, but the likelihood of problems seems to be small. Nevertheless, some manufacturers of selegiline advise avoiding the combination of tricyclic antidepressants and selegiline. The manufacturers of rasagiline advise caution if it is given with antidepressants.