MAOIS AND MAPROTILINE
Toxic and sometimes fatal reactions (similar to or the same as serotonin syndrome) have very occasionally occurred in patients taking both MAOIs and tricyclic antidepressants. Maprotiline would be expected to interact similarly.
Avoid concurrent use. Maprotiline should not be started for 2 weeks after treatment with MAOIs has been stopped and an MAOI should not be started until at least 7 to 14 days after maprotiline has been stopped. If concurrent use is thought necessary it has been suggested that it should only be undertaken by those well aware of the problems and who can undertake adequate supervision.
Avoid concurrent use. Maprotiline should not be started for 2 weeks after treatment with MAOIs has been stopped and an MAOI should not be started until at least 7 to 14 days after maprotiline has been stopped. If concurrent use is thought necessary it has been suggested that it should only be undertaken by those well aware of the problems and who can undertake adequate supervision.