MAOIS AND TRAZODONE
Toxic and sometimes fatal reactions (similar to or the same as serotonin syndrome) have very occasionally occurred in patients taking both MAOIs and tricyclic
antidepressants. A case report suggests that trazodone may interact similarly.
Trazodone should not be started for 2 weeks after treatment with MAOIs has been stopped, and an MAOI should not be started until 1 week after trazodone has been stopped. If concurrent use is thought necessary it has been suggested that it should only be undertaken by those well aware of the problems and who can undertake adequate supervision. The US manufacturers suggest starting at low doses, and increasing cautiously.
antidepressants. A case report suggests that trazodone may interact similarly.
Trazodone should not be started for 2 weeks after treatment with MAOIs has been stopped, and an MAOI should not be started until 1 week after trazodone has been stopped. If concurrent use is thought necessary it has been suggested that it should only be undertaken by those well aware of the problems and who can undertake adequate supervision. The US manufacturers suggest starting at low doses, and increasing cautiously.