MEFLOQUINE AND RIFAMPICIN (RIFAMPICIN)
Rifampicin reduces the AUC of mefloquine by almost 70%.
The clinical relevance of this is uncertain, but some suggest that simultaneous use should be avoided to prevent treatment failure and the risk of Plasmodium falciparum resistance to mefloquine. Until more is known, this would seem a sensible precaution.
The clinical relevance of this is uncertain, but some suggest that simultaneous use should be avoided to prevent treatment failure and the risk of Plasmodium falciparum resistance to mefloquine. Until more is known, this would seem a sensible precaution.