MEROPENEM AND VALPROATE
Meropenem and other carbapenems appear to dramatically and rapidly reduce valproate levels resulting, in some cases, in increased seizure frequency.
It would be prudent to monitor valproate levels in any patient given carbapenems. The valproate dosage may need to be increased. Consider using another antibacterial, or an alternative to valproate. Limited evidence suggests that carbamazepine and phenytoin are not affected.
It would be prudent to monitor valproate levels in any patient given carbapenems. The valproate dosage may need to be increased. Consider using another antibacterial, or an alternative to valproate. Limited evidence suggests that carbamazepine and phenytoin are not affected.