MEXILETINE AND OPIOIDS
The absorption of mexiletine is reduced in patients following a myocardial infarction, and very markedly reduced and delayed if opioids (diamorphine or morphine) are given concurrently.
The delay and reduction in the absorption would seem to limit the value of oral mexiletine during the first few hours after a myocardial infarction, particularly if opioid analgesics are used. The manufacturer suggests that a higher loading dose of oral mexiletine may be preferable in this situation. Alternatively, an intravenous dose of mexiletine may be given.
The delay and reduction in the absorption would seem to limit the value of oral mexiletine during the first few hours after a myocardial infarction, particularly if opioid analgesics are used. The manufacturer suggests that a higher loading dose of oral mexiletine may be preferable in this situation. Alternatively, an intravenous dose of mexiletine may be given.