MEXILETINE AND PHENYTOIN
Phenytoin halves the AUC of mexiletine. Fosphenytoin, a prodrug of phenytoin, may interact similarly.
It seems likely that the fall in mexiletine levels will be clinically important in at least some individuals. Monitor for mexiletine efficacy, and where possible monitor mexiletine levels. Raise the dosage if necessary.
It seems likely that the fall in mexiletine levels will be clinically important in at least some individuals. Monitor for mexiletine efficacy, and where possible monitor mexiletine levels. Raise the dosage if necessary.