MEXILETINE AND RIFAMPICIN (RIFAMPIN)
The clearance of mexiletine is increased by rifampicin. The mexiletine AUC was
reduced by 40% in one study.
It seems likely that the fall in mexiletine levels will be clinically important in some
individuals. Monitor for mexiletine efficacy, and where possible monitor
mexiletine levels. Raise the dosage if necessary.
reduced by 40% in one study.
It seems likely that the fall in mexiletine levels will be clinically important in some
individuals. Monitor for mexiletine efficacy, and where possible monitor
mexiletine levels. Raise the dosage if necessary.