MEXILETINE AND TERBINAFINE
In vitro studies suggest that terbinafine is an inhibitor of CYP2D6. It may therefore be expected to increase the plasma levels of other drugs that are substrates of this enzyme, such as mexiletine.
Until more is known it would seem wise to be aware of the possibility of an increase in adverse effects if mexiletine is given with terbinafine and consider a dose reduction if necessary.
Until more is known it would seem wise to be aware of the possibility of an increase in adverse effects if mexiletine is given with terbinafine and consider a dose reduction if necessary.