MIDAZOLAM
Carbamazepine reduces the AUC and peak serum levels of midazolam by about 90%, when compared with control subjects not taking antiepileptics. The effects of midazolam were also reduced.
Expect to need to use a much larger dose of midazolam in the presence of carbamazepine. An alternative hypno-sedative may be needed.
Other benzodiazepines
The use of benzodiazepines with carbamazepine is common, although some evidence suggests that the effects of the benzodiazepines are sometimes reduced (alprazolam, clonazepam, diazepam, zopiclone).
No action needed, but be aware that sometimes the effects of the benzodiazepines may be reduced.
Expect to need to use a much larger dose of midazolam in the presence of carbamazepine. An alternative hypno-sedative may be needed.
Other benzodiazepines
The use of benzodiazepines with carbamazepine is common, although some evidence suggests that the effects of the benzodiazepines are sometimes reduced (alprazolam, clonazepam, diazepam, zopiclone).
No action needed, but be aware that sometimes the effects of the benzodiazepines may be reduced.