MIRTAZAPINE AND PHENYTOIN
Mirtazapine does not appear to affect the pharmacokinetics of phenytoin. Phenytoin decreases the AUC and maximum plasma levels of mirtazapine by 47% and 33%, respectively. Fosphenytoin, a prodrug of phenytoin, may interact similarly.
The mirtazapine dose may need to be increased in the presence of phenytoin. Monitor concurrent use to ensure mirtazapine is effective.
The mirtazapine dose may need to be increased in the presence of phenytoin. Monitor concurrent use to ensure mirtazapine is effective.