MOCLOBEMIDE AND NASAL DECONGESTANTS

Limited evidence suggests that blood pressure elevations may occur when patients taking moclobemide are given nasal decongestants with indirect sympathomimetic actions, such as ephedrine. However, these rises in blood pressure do not seem to be as large as those seen with the non-selective MAOIs. Ephedrine has been successfully and uneventfully used in the presence of moclobemide (omitted on the day of surgery) during anaesthesia to control hypotension.
The manufacturers of moclobemide advise avoiding drugs such as ephedrine, pseudoephedrine and phenylpropanolamine.