MOCLOBEMIDE AND OPIOIDS

One report suggests that on the basis of animal studies the combination of moclobemide and pethidine (meperidine) should be avoided or used with caution. A report of suspected serotonin syndrome in a patient given pethidine (meperidine) in addition to her usual treatment with moclobemide, nortriptyline and lithium, adds some weight to this suggestion. Similar predictions have been made for tramadol, and serotonin syndrome, has been seen in a patient given tramadol with moclobemide and clomipramine.
Concurrent use should be avoided or undertaken with great caution.