MOCLOBEMIDE AND SSRIS
Some studies suggest that moclobemide may not interact with the SSRIs, but there have been case reports of serotonin syndrome, in patients taking the combination.
Concurrent use is contraindicated. Because the effects of moclobemide are readily reversible, only one day need elapse between stopping moclobemide and starting an SSRI. However, if stopping an SSRI and starting moclobemide the same intervals as for the irreversible MAOIs are required. The manufacturers say that any type of MAOI should not be added until sertraline has been stopped for 14 days, or citalopram, escitalopram, fluvoxamine or paroxetine have been stopped for 7 days, (14 days in the US). The manufacturers of fluoxetine recommend that at least 5 weeks should elapse between stopping the fluoxetine and starting the MAOI. A longer interval is suggested if long-term or high-dose fluoxetine has been used.
Concurrent use is contraindicated. Because the effects of moclobemide are readily reversible, only one day need elapse between stopping moclobemide and starting an SSRI. However, if stopping an SSRI and starting moclobemide the same intervals as for the irreversible MAOIs are required. The manufacturers say that any type of MAOI should not be added until sertraline has been stopped for 14 days, or citalopram, escitalopram, fluvoxamine or paroxetine have been stopped for 7 days, (14 days in the US). The manufacturers of fluoxetine recommend that at least 5 weeks should elapse between stopping the fluoxetine and starting the MAOI. A longer interval is suggested if long-term or high-dose fluoxetine has been used.