MOCLOBEMIDE AND TRIPTANS
Moclobemide markedly inhibits the metabolism of rizatriptan, modestly inhibits the metabolism of zolmitriptan and approximately doubles the bioavailability of sumatriptan. Note that there is a potential risk of serotonin syndrome, if triptans are given with moclobemide.
The manufacturers contraindicate the use of moclobemide with rizatriptan or sumatriptan. In the UK, a maximum intake of 5 mg of zolmitriptan in 24 hours is recommended by the manufacturers, whereas in the US the combination is contraindicated.
The manufacturers contraindicate the use of moclobemide with rizatriptan or sumatriptan. In the UK, a maximum intake of 5 mg of zolmitriptan in 24 hours is recommended by the manufacturers, whereas in the US the combination is contraindicated.