NNRTIS AND OPIOIDS
Methadone plasma levels can be markedly reduced by efavirenz or nevirapine, and methadone withdrawal symptoms have been seen.
If efavirenz or nevirapine are added to established treatment with methadone, be alert for evidence of opiate withdrawal, and raise the methadone dose accordingly. Some patients may require an increase in the methadone dose frequency to twice daily. In patients who subsequently discontinue the NNRTI, the methadone dose should be gradually reduced.
If efavirenz or nevirapine are added to established treatment with methadone, be alert for evidence of opiate withdrawal, and raise the methadone dose accordingly. Some patients may require an increase in the methadone dose frequency to twice daily. In patients who subsequently discontinue the NNRTI, the methadone dose should be gradually reduced.